Will LEDGIN molecules be able to play a role in a cure for HIV infection?
نویسندگان
چکیده
Article history: Received 5 May 2016 Accepted 5 May 2016 Available online 7 May 2016 lishment of latency, as the cellular transcriptional state influences both HIV transcription driven by its promoter located in the long terminal region (LTR) and reactivation from latency. Inhibitors that target the interaction between integrase and LEDGF are variously termed noncatalytic integrase inhibitors (NCINIs), allosteric inhibitors (ALLINIs), or LEDGF inhibitors (LEDGINs). The molecular mechanisms by which
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